The invention provides a novel hole arrangement grouting method for enabling a ground pre-grouting reinforcing roadway to penetrate through surrounding rocks at a fault fracture zone. The method comprises the following steps: (1), computing the hole pitch of drill holes according to the grout diffusion radius in the direction of the roadway; (2), drilling a vertical grouting straight hole which can extend to the initial positions of roadway roof grouting branch holes along the positions of the designed drill holes; (3), drilling the inverted Y-shaped grouting branch holes for grouting; (4), determining the grout proportion, performing reinforced grouting on rocks at the fault fracture zone. According to the invention, a directional branching technology is adopted, so that the grouting range is expanded; the ground pre-grouting can be implemented, so that the grouting pressure is high, and the grouting effect is excellent; the grout is adopted for reinforcing, so that the price is relatively cheap, and the integral strength of the reinforced rocks is high; the method has wide practicability and high simplicity in operation.