The invention discloses a multi-source heterogeneous data semantic integrated model constructed based on domain ontology. The multi-source heterogeneous data semantic integration model comprises a local ontology constructing module, a domain ontology merging module and a semantic inquiring dynamic propagation and protocol module. A multi-source heterogeneous data semantic integrating method comprises the following steps: constructing the domain ontology through an ontology merging technique and establishing a semantic mapping relation between a data source and the local ontology as well as between the local ontology and the domain ontology; combining the complementary advantage of social label and ontology on knowledge representation and performing inquiring protocol and propagation for the semantic inquiring request of the user, thereby generating a formal semantic inquiring statement; respectively inquiring a plurality of data sources, performing duplicate removal and aggregation optimization on the inquiring result, and lastly feeding back to the user. The invention provides an aggregation heterogeneous data semantic integration model constructed based on domain ontology and the method through the construction and mapping of the domain ontology, semantic inquiring propagation and result aggregation optimization.