The invention relates to an isolated grid operation stabilization control method based on a delivery manner of a regional weak tie power grid. The method is a dynamic simulation analyzing method based on tracks. According to a searching-verifying method and combining the voltage and frequency change tracks, the operating characteristics of the power grid under the condition of various delivery power are analyzed, the factors of the unit grid interfering protection of the regional power grid, the operating state change of the power grid, the over-speed protection of a generator unit, the high-week machine cutting measures of the regional power grid, linked machine cutting, low-frequency load decrease and the like are comprehensively considered, an isolated grid operation stabilization control strategy which is suitable for the delivery regional power grid for the requirements of the actual power grid is developed, and the second defense line and the third defense line of the regional power grid, and the over-speed protection allocation scheme of a generator are coordinated and optimized. Through the adoption of the stabilization control method, the isolated grid operation stabilization of the regional power grid can be ensured, the load loss can be reduced, the adaptability is better, the considered factors are more comprehensive, the certain practical value can be generated, and the promoted prospect is better.