The invention provides a manufacturing method for fluorine plastic injection outside a glass lining workpiece. The manufacturing method is characterized by comprising the following steps: step one, carrying out thorough clearing sand blasting on the surface of a metal blank body, and then enameling a ceramic glaze coating with uniform thickness on the surface; step two, uniformly spraying a fluorine plastic layer on the surface of the glass lining workpiece, and spraying on the surface of the glass lining workpiece in sequence, wherein the fluorine plastic layer is divided into a base material, a middle material and a surface material; step three, clearing the surface, and carrying out 20kv high-voltage discharge test to complete the preparation of the workpiece. The method for preparing the workpiece is wider in applicable medium, the surging range of temperature difference is improved, and the method has the obvious advantages of good medium permeability resistance, long service life, lower cost and the like; a PFA (Perfluoroalkoxy alkane) coating sprayed on the surface can compensate the defects of dark bubbles, pinholes and the like which are undetected by glass lining equipment; the temperature difference surging resistance of the equipment is further increased, and the risk of glass lining explosion caused by temperature difference surging is reduced.