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发明公开
CN104220420A 一种长效β-2肾上腺素受体激动剂的新型多晶 有权 转让

一种长效β-2肾上腺素受体激动剂的新型多晶
摘要：
一种长效β-2肾上腺素受体激动剂的新型多晶。本发明提供了一种酒石酸阿福特罗的新型多晶D型，其至少具有以下特征之一：(i)X射线粉末衍射图谱在2θ值约为6.8，13.3，13.6，3.8，14.1，18.2，18.7，20.0±0.2度出峰；或(ii)DSC热分析谱图显示吸热峰大致起始于19-120℃，约在129-131℃达到最大值，随后放热峰约在137-138℃达到最大值；其中，晶型D的DSC热分析谱图在约168-170℃开始还有一吸热。本发明还提供了所述新型多晶的制备方法、其用途和其中间体。
摘要（英）：

Provided is a new polymorphic form of a long-acting beta-2 adrenoceptor agonist. A new polymorphic form of arformoterol tartrate, designated as form D, is provided and which is characterised by at least one of the following: (i) a powder X-ray diffraction pattern having peaks at approximately 6.8, 13.3, 13.6, 3.8, 14.1, 18.2, 18.7, 20.0 +-0.2 degrees two theta; or (ii) a DSC thermogram showing an endothermic peak with an onset at approximately 19-120 DEG C, and a maximum at approximately 129-131 DEG C, followed by an exothermic peak with a maximum at approximately 137-138 DEG C; wherein the DSC thermogram of form D has a further endothermic peak with an onset at approximately 168-170 DEG C.1 Processes for preparing the new polymorphic form, uses thereof and intermediates for the preparation thereof, are also provided.

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