An extensible hub is disclosed for providing multi-hop wireless communication among universal serial bus (USB) devices, for example, utilizing a WiGig Serial Extension (WSE) air interface. The extensible hub may include a device protocol adaptation layer (PAL), as well as a host PAL, and further a bridge for providing a data flow path between the device and host PALs. The bridge may be configured to distinguish between request messages and response messages in accordance with a header on those messages. Further, the extensible hub may include virtual ports and may map device handles and endpoint handles to provide for routing of messages to the correct downstream devices in a multi-hop network tree.