The invention discloses a trimethyl ester nitrogen filled protection washing reaction device, belonging to the field of chemical equipment. The device is connected with a nitrogen filling mechanism through a pipeline by a washing kettle. A water inlet pipe is arranged above the washing kettle and stretches into the bottom of the washing kettle; a water outlet pipe is arranged at the bottom of the washing kettle; an air inlet and an air outlet are formed in the upper end of the washing kettle; the air inlet is connected with the nitrogen filling mechanism through a pipeline; the nitrogen filling mechanism comprises an air compressor, a nitrogen making machine and an air storage tank which are sequentially connected through pipelines; and the air storage tank is connected to the washing kettle through a pipeline. The trimethyl ester nitrogen filled protection washing reaction device disclosed by the invention has the advantages that materials are stably polymerized, the safety in the production process is further improved, the production cost is reduced, the wastes are recycled through a material sedimentation tank, the environmental protection is facilitated, the waste of the materials is reduced and the like.