The invention provides a sandwich type structure based physical sterilization device. The specific technical scheme is that the physical sterilization device comprises an upper vibration plate, a vibration excitation element of the upper vibration plate, a lower vibration plate, a vibration excitation element of the lower vibration plate, a sterilization plate and a support structure, wherein the sterilization plate is located between the upper vibration plate and the lower vibration plate to form a sandwich type structure, and by virtue of upper and lower ultrasonic fields and the sterilization plate, viruses, bacteria and fungi in fluids of the ultrasonic fields are killed. The upper and lower ultrasonic fields can have nonlinear effects such as acoustic radiation force, acoustic stream and the like, the nonlinear effects can drive the viruses, the bacteria and the fungi in the fluids of the ultrasonic fields to the surface of the sterilization plate, a nano sterilization material such as a nano TiO2 coating on the sterilization plate can play a role sufficiently, meanwhile, heat for heat treatment of the sterilization plate can be taken to the fluids of the ultrasonic fields by means of the nonlinear effects, and killing of the viruses, the bacteria and the fungi in the fluids is facilitated.