The invention discloses a non-artificial roadway filling and non-coal-pillar gob-side entry retaining method for an inclined medium-thickness coal seam. The method comprises the following steps: performing basic support in roadway construction, performing advance support within 30m in front of a coal mining face; digging out an advance gap in the coal mining face, and performing advance gap reinforced support in the advance gap, performing lagging support in the roadway being 60m behind the coal mining, wherein the area being 60m behind the coal mining face is a gob-side entry retaining stabilizing area. By using movement conditions of different roofs for positions with the distances different from the coal mining face in a goaf and adopting different support modes, effective support can be achieved, the goaf can be subjected to roof cutting, and also the support cost is low, so that the non-coal-pillar gob-side entry retaining is successful.