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发明公开
CN104267188A 针对MSK1基因的相关制剂在制备5-FU耐药性检测试剂及5-FU耐药逆转剂方面的应用 失效 - 权利终止 转让

针对MSK1基因的相关制剂在制备5-FU耐药性检测试剂及5-FU耐药逆转剂方面的应用
摘要：
本发明属于生物医药领域，涉及5-FU耐药性检测试剂及5-FU耐药逆转剂，更具体地说，涉及MSK1相关制剂在制备5-FU耐药性检测试剂及5-FU耐药逆转剂方面的应用。5-FU药物耐药性/敏感性与细胞MSK1表达量之间具有显著的关联性。当细胞低表达MSK1时，对5-FU药物的敏感性高；反之，当细胞高表达MSK1时，对5-FU药物的敏感性降低。本发明首次提供了MSK1表达量检测试剂或测试系统在制备5-FU药物耐药性/敏感性检测试剂中的应用；以及MSK1表达抑制剂在制备5-FU药物增敏剂/耐药逆转剂方面的应用。
摘要（英）：

The invention belongs to the field of biomedicine, relates to a 5-FU drug resistance detection reagent and a 5-FU drug resistance reversal agent, and more specifically relates to applications of related preparations aiming at MSK1 gene in preparation of 5-FU drug resistance detection reagent and 5-FU drug resistance reversal agent. A prominent relevance exists between the drug resistance/sensitivity of 5-FU drugs and the cell MSK1 expression amount. When a cell has a low MSK1 expression amount, the cell is high sensitive to 5-FU drugs. When a cell has a high MSK1 expression amount, the sensitivity of the cell on 5-FU drugs is reduced. The invention provides applications of MSK1 expression amount detection reagent or testing system in preparation of detection reagents for detecting the drug resistance/sensitivity of 5-FU drugs for the first time, and further discloses the applications of a MSK1 expression inhibitor in preparation of 5-FU drug sensitizer/resistance-reversal agent.

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