The invention provides an anemometry network layout optimization method based on reanalysis data. The method includes the following steps that the reanalysis data are selected; an anemometry network layout is optimized through a genetic algorithm; whether the effective coverage area of the anemometry network layout meets an end condition or not is judged, if yes, an optimized anemometer tower layout is output, and if not, the last step is continuously executed. Based on an existing anemometer tower, the correlation between different grids of the reanalysis data serves as evaluation indexes for region wind regime representation, the genetic algorithm is adopted, and then the anemometry network layout is optimized. Along with differences of problem varieties and enlargement of problem scales, search and optimization can be well achieved with limited price, and the method has good robustness and engineering practicality.