The invention relates to a rapid cultivating method for a high-yield and high-quality multiple resistant rice restorer. The method comprises the steps of selecting eight rice species having the characters of high yield, high quality, insect resistance and disease resistance as parents, hybridizing every two parents with different target characters to obtain four first-filial generations F1; hybridizing every two of the four F1 to obtain two composite cross generations F1; performing molecular marker-assisted selection on the two composite cross generations F1 single plants in a seedling stage, screening two composite cross generations F1 integrating target genes, carrying out matched hybrid to obtain multiple composite cross generations F1; performing molecular marker-assisted selection on the multiple composite cross generations F1 single plants in a seedling stage to obtain a single plant integrating all target genes, carrying out anther culture to obtain H0 generation anther-culture lines, screening diploid lines; performing molecular marker-assisted selection, agronomic characters, quality and resistance screening on H1 generations to obtain a target high-yield and high-quality multiple resistant rice restorer, carrying out combined test with a series of two-line sterile lines, and screening out advantageous combination.