The invention discloses a power grid loss reduction potential analysis method based on load-grid-source interactive features. The method is characterized by including the steps that data are prepared, grid loss factors with the small association degree are removed, a GM (1 and N) prediction model is established, and the loss reduction potential of the grid loss factors is calculated. The specific implementation steps are shown in the figure attached to the abstract. The method is used for evaluating the potential of all impact factors in the aspect of system loss reduction, and provides a basis for an electric power department to take loss reduction measures.