The invention belongs to the technical field of dispatching automation of an electric power system, and relates to a power generation schedule optimization method taking a hydroelectric generating set vibration area into account. The power generation schedule optimization method is based on current and real-time power generation schedule planned input and output data and includes the steps of reading the data of system load prediction, new energy prediction, the overhaul schedule, the section limit, set stop information, the set reference schedule and the information of sensitivity of a set to a monitoring element, taking various constraints including the system balance constraint, the set operating constraint, the network safety constraint, the set group constraint and the like into comprehensive consideration, maintaining the data of the output range of the hydroelectric generating set vibration area based on a common optimization model, introducing the constraints of the hydroelectric generating set vibration area and forming a mathematic model taking the constraints of the hydroelectric generating set vibration area into account. The optimization model makes a more reliable, effective and practical set output schedule, improves the execution efficiency of the set schedule, relieves the adjustment pressure of an AGC frequency modulation set and an AGC autonomous control set, improves the closed loop level of the current schedule, the real-time schedule and the AGC, and meets the increasingly lean large power grid safe operation requirement.