The invention discloses a pollution-free zero-pollution zero-residue tobacco bud suppression agent which is a liquid mixture of kerosene and 99.7% absolute ethanol in the mass ratio of 20: 80. The use method is that: first preparing a bud suppression agent liquid for standby use; then preparing for bud suppression, to be more specific, selecting a tobacco plant with tobacco buds, from top to bottom hanging a plate for labeling on 2nd, 3th and 4 th leaf positions for preparing for bud suppression; artificially picking buds of tobacco plant tobacco buds with the length greater than or equal to 3 cm, dipping the tobacco bud suppression agent liquid with a brush pen to coating the section, when the length of the tobacco plant tobacco buds is less than or equal to 3 cm, dipping the tobacco bud suppression agent liquid with the brush pen to coating the tobacco plant tobacco buds directly; after processing, inspection is performed once every 3-5 day, in the process, according to the order of germination of the tobacco buds in the field, the tobacco buds are successively applied with the suppression agent for bud removal. The pollution-free zero-pollution zero-residue tobacco bud suppression agent has the advantages of simple preparation, low cost, no waste of rapeseed oil resources, safety to human and livestock, and significant effect, after coating, the tobacco buds may not grow, the consumption of nutrition of lateral buds can be reduced, pesticide residues of chemical bud removal can be eliminated, and the pollution-free zero-pollution zero-residue tobacco bud suppression agent is suitable for tobacco planting.