The invention discloses a fixture for drilling positioning holes in pump bodies of super-huge type water ring vacuum pumps and belongs to the field of fixtures for manufacturing water ring vacuum pump equipment. The fixture comprises a workbench and is characterized in that a bottom plate (12) is arranged above the workbench through a positioning support assembly; a plurality of groups of bilaterally symmetrical V-shaped supporting seats are arranged above the bottom plate (12); the lower part of each V-shaped supporting seat (1) is provided with a lead screw transmission device capable of driving the V-shaped supporting seat (1) to slide horizontally; a pump body tensioner is arranged on one side of each set of V-shaped supporting seat (1) and lead screw transmission device; the positioning support assembly comprises a plurality of bottom plate supporting seats (8) and bottom plate supporting lean iron blocks (9), which are arranged below the bottom plate (12), and bottom plate adjusting seats (3) symmetrically arranged at four corners of the bottom plate (12). The fixture for drilling the positioning holes in the pump bodies of the super-huge type water ring vacuum pumps can conveniently clamp and fix the pump bodies of the super-huge type water ring vacuum pumps, and the pump body processing and drilling efficiency and accuracy are improved.