The invention relates to a real-time automatic generation control machine set scheduling method giving consideration to variable load of wind power and thermal power, belonging to the technical field of operation and control of power systems. The method comprises the steps of: identifying a network loss sensitivity matrix of a system based on real-time measured data of PMU (Power Management Unit) by utilizing a recursive least-squares method, and representing system power balance restriction by utilizing the network loss sensitivity matrix; carrying the quick load change capability of a thermal power generating unit as an optimal object into a mathematic model, carrying out non-dimensional treatment on an objective function which gives consideration to economical efficiency and rapidity, and putting forward the mathematic model which gives consideration to load change capability and rapidity of the thermal power generating unit. According to the method, the network loss sensitivity matrix is identified in real time by fully utilizing the measured data of the PMU; meanwhile, the quick load change capability index of the thermal power generating unit is carried in the objective function to fully cope with rapid variability of the wind power, so that real-time scheduling and control of the power system is facilitated.