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发明公开
CN104334732A 表达人λ免疫球蛋白轻链可变结构域的动物 有权

表达人λ免疫球蛋白轻链可变结构域的动物
摘要：
本发明公开了产生嵌合人-非人抗体和嵌合抗体链的方法，如此产生的抗体和抗体链及其衍生物，包括完全人源化抗体；包含所述抗体、抗体链和衍生物的组合物，以及适用于所述方法的细胞、非人哺乳动物和载体。
摘要（英）：

The invention discloses methods for the generation of chimaeric human - non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.

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