The invention provides a double-side printing parameter generation method, a double-side printing method, a device and a system. The double-side printing parameter generation method comprises the following steps: printing double sides of a piece of testing sample paper by using printing equipment according to preset front side printing parameters and preset back side printing parameters so as to obtain a testing sample printing page; respectively detecting front side effect indexes of the front side printing effect and the back side effect indexes of the back side printing effect of the testing sample paper; comparing the front side effect indexes and the back side effect indexes with standard effect indexes respectively so as to obtain compassion result; according to the compassion result, confirming front side printing parameters and back side printing parameters for printing double sides of a page to be printed, and storing in the printing equipment, wherein the page is made of a material and has the attribute the same as those of the testing sample paper. The problem that in the prior art the printing parameters used for printing the front side and the back side of the page to be printed are not reasonable is solved. The invention relates to the technical field of printing.