The present invention provides a spray bottle cap comprising a base lid, a pressing head and a protective cap. An upper end of an inner wall of the base lid is provided with a first limit rib and a first guide groove penetrating the first limit rib. The pressing head connects to the upper end of the base lid, and comprises a outlet rob, a pressing handle and a connection portion, where the outlet rod is provided with an outer thread, the lower end of the connection portion is provided with a first limit flange and a protrusion portion, and the pressing handle is provided with an anti-reversion snap parent body; the first limit flange is arranged under the first limit rib, and the protrusion portion is up-down slidable along the first guide groove and is supportable on the upper end face of the base lid. The protection cap is a double-layer structure covering the outside of the outlet rod, where the inner layer is provided with an inner thread matched with the outer thread of the outlet rod, and the lower end of the outer layer is provided with a daughter body matched with the anti-reversion snap parent body. The present invention also provides a sprayer bottle comprising a bottle body and a sprayer, where the mouth of the bottle body is connected to the spray bottle cap. The present invention is safe, and is less-laborious and convenient in operation.