The invention belongs to the technical field of agriculture, and particularly relates to a special compound fertilizer for flue-cured tobacco variety K326 and application thereof. The special compound fertilizer for flue-cured tobacco variety K326 contains 7.5-8.5% of nitrogen, 7.5-8.5% of phosphorus and 23-25% of potassium. When the compound fertilizer is used for planting the flue-cured tobacco variety K326, the tobacco plant has favorable integral growth vigor and high disease tolerance, and the incidence rate of black shank is lowered by 3.3-6.66%. Various agronomic character values are excellent, and the waist leaf length and width are respectively increased by 13.85-20.97% and 12.5-21.74%. The total nitrogen, nicotine, total sugar, reducing sugar, tobacco potassium, sugar/base ratio and nitrogen/base ratio of the tobacco are respectively within a proper range. The compound fertilizer can effectively enhance the appearance quality of the tobacco, increase the tobacco aroma and potassium content, improve the taste of the tobacco and enhance the yield and quality of the tobacco, and is applicable to batch planting of the flue-cured tobacco variety K326.