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发明公开
CN104367690A 一种水包油型复方洛美沙星纳米乳 无效 - 驳回

一种水包油型复方洛美沙星纳米乳
摘要：
一种水包油型复方洛美沙星纳米乳，属于医药技术领域，所述纳米乳的重量组成为：鱼腥草水提物1～20份、表面活性剂5～40份、助表面活性剂1～15份、洛美沙星1～25份、油1～25份、水20～70份。本发明的纳米乳的乳液粒径分布较窄，体系透明、稳定性好，有较低的表面张力，具有很好的流动性，服用方便，纳米乳制剂提高了洛美沙星的溶解度和渗透性，使得药物的生物利用度得到改善；鱼腥草水提物与洛美沙星复合，两者的抗菌能力能够得到相互促进和提升，抗菌效果更加稳定。
摘要（英）：

The invention discloses an oil-in-water type compound lomefloxacin nano-emulsion, belonging to the technical field of medicines. The nano-emulsion comprises the following components in parts by weight: 1-20 parts of herba houttuyniae aqueous extract, 5-40 parts of surfactant, 1-15 parts of co-surfactant, 1-25 parts of lomefloxacin, 1-25 parts of oil and 20-70 parts of water. The nano-emulsion disclosed by the invention is relatively narrow in latex particle size distribution, transparent in system and good in stability, has relatively low surface tension and very good fluidity, is convenient to take, and improves the solubility and penetrability of lomefloxacin to ensure that the bioavailability of a medicament is improved; and the herba houttuyniae aqueous extract is compounded with lomefloxacin, so that the antibacterial abilities of the two are mutually promoted, and the antibacterial effect is more stable.

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