The invention relates to the technical field of water treatment, and particularly relates to and discloses a treatment method for zero discharge of high-hardness high-salinity wastewater. The method comprises the steps of pretreating; ultrafiltering in a first section; carrying out reverse osmosis treatment in the first section; carrying out enhancing treatment on reverse osmosis concentrate in the first section; filtering by multiple mediums, softening, and ultrafiltering and carrying out reverse osmosis treatment in a second section; passing the reverse osmosis concentrate in the second section through a nano-filtration device; passing nano-filtration permeate through an electrodialysis device; introducing fresh water generated by the electrodialysis device into ultrafiltration water of the second section, and taking concentrate in the electroldialysis device for regenerating a softener; feeding nano-filtration concentrate into an evaporation system to obtain a solid matter, and taking water in reverse osmosis treatment of the first and second sections as reuse water. According to the treatment method for zero discharge of high-hardness high-salinity wastewater, physicochemical treatment, membrane integration technology and evaporation technology are combined, so that the problem that the environment is polluted by high-hardness high-salinity concentrate discharge can be effectively solved, the requirement for zero discharge can be met, the effluent water quality is stable, and the water utilization rate is improved.