The invention belongs to the technical field of cables, and particularly relates to a high-voltage cable for the interior of an electric automobile. The high-voltage cable comprises a conductor, wrapping tape, an insulation layer and a sheath layer and is characterized in that the conductor is composed of a plurality of annealed fifth soft aluminum wires or galvanized aluminum wires or tinning aluminum wires with the diameter of 0.05 mm to 0.60 mm; the cross section area of the conductor is 1.5 mm square to 120 mm square; the insulation layer is made of environmental-friendly inflaming retarding TPE at the temperature of 125 DEG C; the sheath layer is made of environmental-friendly inflaming retarding thermoplastic elastomer TPU at the temperature of 125 DEG C. The invention further discloses a manufacturing method of the cable. The cable has the main advantages of being flexible, easy to bend and construct, small in self weight, low in cost, resistant to high voltage, large current, high temperature and electrical disturbance, good in inflaming retarding effect, good in bending-resisting performance and safe to use.