The invention discloses a transfusion packaging bag unpackaging machine. The transfusion packaging bag unpackaging machine comprises a conveyor belt and driving wheels, wherein the conveyor belt is used for conveying a packaging bag, the driving wheels are used for driving the conveyor belt, the outer side of the conveyor belt in the width direction is provided with a pair of disc shears which are vertically arranged and are parallel to the conveying direction of the conveyor belt, a shearing zone of a bag opening of the packaging bag is formed in a way that the two disc shears are overlapped and staggered, a first supporting wheel of which the horizontal position is higher than the driving wheels is arranged under the conveying surface of the conveyor belt, and the first supporting wheel is positioned in front of the shearing zone along the conveying direction of the conveyor belt and is positioned at one side, which is opposite to the disc shears, of the conveyor belt in the width direction. According to the transfusion packaging bag unpackaging machine disclosed by the invention, the disc shears can be used for shearing off a transfusion packaging bag on the conveyor belt, the transfusion packaging bag is enabled to fall from the conveyor belt by utilizing the tilting of the conveyor belt, thus the automatic control from the unpackaging of the transfusion packaging bag to the taking of the transfusion packaging bag can be completed, the labor intensity of a nurse is greatly reduced, and the working efficiency is increased.