The invention provides a 500 kV/220 kV power grid partitioning strategy evaluation method. The method comprises the following steps: automatic topology discovery of 220 kV power grid tie line; generating a primary power grid partitioning strategy set; screening the power grid partitioning strategies to obtain the power grid partitioning strategy meeting the requirements; comprehensively evaluating the power grid partitioning strategy, and ranking the power grid partitioning strategies in each partitioning strategy set. The 500 kV/220 kV power grid partitioning strategy evaluation method is able to automatically provide theoretically possible partitioning strategy set for the actual power grid structure, and then obtain the power grid partitioning strategy set by verifying the short-circuit current, tidal current and static safety of each partitioning strategy. The 500 kV/220 kV power grid partitioning strategy evaluation method makes up the defects of the conventional partitioning method that the partitioning strategy aiming at the actual power grid characteristic of a certain region is determined based on human experience, thus further increasing the scientificity and efficiency of 500 kV/220 kV power grid partitioning.