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发明公开
CN104404056A 一种重组副猪嗜血杆菌免疫保护性抗原HbpA2及其制备方法 有权

一种重组副猪嗜血杆菌免疫保护性抗原HbpA2及其制备方法
摘要：
本发明公开了一种如SEQ ID NO：1所示的核苷酸序列，公开了包含该核苷酸序列的重组载体、重组菌，以及SEQ ID NO：1所示的核苷酸序列编码的重组HbpA2蛋白及其制备方法。本发明重组HbpA2蛋白良好的免疫原性和保护原性，免疫后产生的HbpA2特异性抗体水平高，可以显著保护小鼠抵抗副猪嗜血杆菌血清5型强毒菌株的攻击，说明重组蛋白HbpA2是副猪嗜血杆菌的保护性抗原，可以制备成为疫苗。
摘要（英）：

The invention discloses a nucleotide sequence as shown in SEQ ID NO:1 and discloses a recombinant vector and recombinant bacteria containing the recombinant bacteria, a recombinant HbpA2 protein coded by the nucleotide sequence as shown in the SEQ ID NO:1 and a preparation method thereof. The recombinant HbpA2 protein has good immunogenicity and protection genicity. The HbpA2 generated after immunization has high specific antibody level and can remarkably protect attacks of mouse anti-haemophilus parasuis serum type-5 strain with strong virulence. It shows that the recombinant protein HbpA2 is a protective antigen for haemophilus parasuis and can be made into a vaccine.

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