The invention relates to an electric power control system, and discloses a high-voltage power distribution cabinet electromagnetic isolation switching on-off system. The high-voltage power distribution cabinet electromagnetic isolation switching on-off system comprises a high-voltage power distribution cabinet, wherein the high-voltage power distribution cabinet is internally provided with a circuit breaker, a primary side of the circuit breaker is provided with a power supply leading-in end, and a secondary side of the circuit breaker is provided with a power supply distribution end. The high-voltage power distribution cabinet is further provided with a switching button. The high-voltage power distribution cabinet is characterized by further comprising a latching relay, a self power generation device and an electric signal output switch, wherein the latching relay is located between the power supply leading-in end and the power supply distribution end, and the latching relay comprises a conduction signal leading-in end; the self power generation device is provided with an electric signal output end, and the electric signal output end is connected to the conduction signal leading-in end; and the switching button acts as the electric signal output switch. Power at the power supply leading-in end can be transmitted to the power supply distribution end through the latching relay, and then is provided for an electrical equipment circuit connected with the power supply distribution end or the circuit breaker.