The invention discloses a manufacturing process of a pre-tensioned prestressed centrifugal concrete square pile. The manufacturing process includes the steps of a, measuring and stirring concrete materials; b, manufacturing end plates of the centrifugal square pile; c, manufacturing a frame; d, mounting the reinforced frame; e, distributing concrete; f, closing a mold; g, performing prestress tensioning; h, performing centrifuging; I, performing primary steam curing; j, performing stripping; and k, directly lifting stripped centrifugal square piles, having concrete design strength level reaching C60, to a product yard for stacking, and delivering out of the factory after natural curing is complete and delivery strength is reached; subjecting the stripped centrifugal square piles, having the concrete design strength level reaching C80 and above, to high-temperature steam curing in a high-pressure autoclave, and directly delivering the piles subjected to the high-pressure curing. The manufacturing process has the advantages that the manufacturing process is simple, manufacturing time is short, fewer materials are used, energy consumption is low, and the manufactured centrifugal pile has high strength and good quality.