An oxygen sensor packaging structure mainly comprises a metal housing, and a ceramic probe, and is characterized in that the structure comprises a first filler and a second filler which are distributed in parallel between the ceramic probe and the metal housing in the axial direction, wherein the volume compression ratios of the first filler and the second filler differ by more than two times. The structure of the invention aims at reducing the riveting stress during packaging by using the first filler and the second filler with different volume compression ratios, and obtains good packaging effect. Meanwhile, the product yield is increased, and the manufacturing cost is decreased.