The invention discloses a tissue box. The tissue box comprises a base, wherein a middle partition board and two box bodies are arranged on the upper surface of the base, the two box bodies are located on the two sides of the middle partition board respectively, the box body is placed on the base, the box body is cuboid, the bottom of the box body is open, a tissue extraction port is formed in the top surface of the box body, the middle partition board is fixedly connected to the base, and retaining sides are arranged around the base. In this way, the tissue box is simple and reasonable in structure, and due to the fact that two box bodies are arranged, the tissue box is suitable for being used in a restaurant, long-term use can be achieved by adding tissue once, and therefore using is convenient.