The invention provides a mucocutaneous disinfectant which comprises the following ingredients in parts by weight: 5-10 parts of chitosan quaternary ammonium salt, 3-5 parts of alkyl dimethyl benzyl ammonium chloride, 5-10 parts of sodium polyoxyethylene nonylphenyl ether sulphate, 5-10 parts of ethanol, 3-5 parts of beewax, 5-10 parts of povidone iodine, 3-5 parts of a surfactant, 1-3 parts of urea and 30-40 parts of deionized water. The mucocutaneous disinfectant provided by the invention has no pungent smell, has low toxicity and weak irritation to skin and eyes, is suitable for mucocutaneous disinfection and has no pollution to environment. Meanwhile, under the combined effect of the active ingredients of the disinfectant, the sterilization and disinfection effects are improved.