The invention discloses a rotating cross-flow type vacuum membrane distillation device. The rotating cross-flow type vacuum membrane distillation device mainly comprise a raw water storage tank, a raw water heating water tank, a rotating cross-flow type hydrophobic membrane module, a condenser, a cooling water tank, a vacuum buffer tank, a vacuum pump and a water production tank. Raw water enters the heating water tank from the raw water storage tank and is heated, hot water is reserved outside the rotating cross-flow type hydrophobic membrane module, steam then enters hollow membrane module units through the membrane and is merged into a hollow shaft under the guiding action of the vacuum pump, further enters the condenser and condensed water flows into the water production tank. During the membrane distillation, the hydrophobic membrane module rotatably runs in a program-controlled manner; by the centrifugal force, hydrodynamic shear force and strong flow turbulence generated by the movement, the self-cleaning of the surface of the permeable membrane is achieved, the influences of concentration polarization and temperature polarization are effectively avoided, the pollution caused by salt crystallization, scaling, a gel layer and organic substances can be decreased, the cleaning period and service life of the permeable membrane module are prolonged and meanwhile, the heat utilization rate of the system is increased.