The invention relates to an anti-caking agent for a chemical fertilizer. The anti-caking agent comprises the following components in percentage by mass: 15 percent of polyamide wax, 28 percent of alkyl dimethyl betaine, 22 percent of Na-acyl lysine, 8 percent of Na-methyl-Na-lauryl lysine, 3 percent of viola, 4 percent of radix peucedani, 1.5 percent of sorbate, and 18.5 percent of polyethylene glycol, wherein the molecular weight of polyethylene glycol is 1,000-1,800. The anti-caking agent for the chemical fertilizer is low in cost, and can effectively avoid the caking of the chemical fertilizer in the processes of storage and transportation; the anti-caking agent can be naturally degraded after being used, so that the reduction of fertilizer efficiency of soils caused by residues is avoided; moreover, active components such as traditional Chinese medicines and the like are added, so that the caking of the chemical fertilizer can be prevented, and the reduction of the fertilizer efficiency caused by oxidization of the chemical fertilizer in the processes of storage and transportation can also be effectively avoided.