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发明授权
CN104447620B 1-[3-[3-(4-氯苯基)丙氧基]丙基]-哌啶盐酸盐的制备方法 有权

1-[3-[3-(4-氯苯基)丙氧基]丙基]-哌啶盐酸盐的制备方法
摘要：
本发明涉及一种1-[3-[3-(4-氯苯基)丙氧基]丙基]-哌啶盐酸盐的制备方法，步骤为：(1)将哌啶和1,3-二卤代丙烷置于水溶性的极性非质子性溶剂中，在碱性化合物作用下，缩合反应得到N-(3-卤丙基)哌啶；(2)N-(3-卤丙基)哌啶与3-(4-氯苯基)丙醇在溶剂中，碱性化合物作用下进行醚化，得到化合物1-[3-[3-(4-氯苯基)丙氧基]丙基]-哌啶；(3)1-[3-[3-4-氯苯基)丙氧基]丙基]-哌啶与HCl反应得到产品。本发明工艺步骤简单，操作方便，原料易得，价格便宜，制备的产物收率高，纯度高，成本低，适合工业化生产。
摘要（英）：

The invention relates to a preparation method of 1-[3-[3-(4-chlorphenyl) propoxy] propyl]-piperidine hydrochloride. The preparation method of 1-[3-[3-(4-chlorphenyl) propoxy] propyl]-piperidine hydrochloride comprises the following steps: (1) putting piperidine and 1,3-dihalogen propane in a water-soluble polar aprotic solvent, and carrying out condensation reaction to obtain N-(3-halide propyl) piperidine under the action of an alkali compound; (2) carrying out etherification on N-(3-halide propyl) piperidine and 3-(4-chlorphenyl) propyl alcohol in the solvent under the action of the alkali compound to obtain a compound, namely 1-[3-[3-(4-chlorphenyl) propoxy] propyl]-piperidine; and (3) enabling the 1-[3-[3-(4-chlorphenyl) propoxy] propyl]-piperidine to react with HCl to obtain the product. The preparation method of 1-[3-[3-(4-chlorphenyl) propoxy] propyl]-piperidine hydrochloride is simple in processing step, convenient to operate, easily available in raw material and low in price; the prepared product is high in yield, high in purity, low in cost and suitable for industrial production.

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