The invention discloses a 2-thiopheneacetonitrile and 2-thiopheneethylamine preparing method. The method is characterized in that by using a palladium catalyst and an organic phosphine ligand, 2-bromothiophene and cyano-acetate are subject to decarboxylation coupling in an organic solvent to obtain 2-thiopheneacetonitrile; and from 2-thiopheneacetonitrile is reduced to obtain 2-thiopheneethylamine. By the method, the cost of production is greatly reduced; the reaction condition is mild, the process is simple, the pollution is less, and the method is conducive to industrial production; and the use of toxic substances is avoided, and the environmental pollution is greatly reduced.