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发明授权
CN104450704B 精神分裂症外周血标志物miR-132及其应用 失效 - 权利终止

精神分裂症外周血标志物miR-132及其应用
摘要：
本发明涉及一种外周血microRNA分子标志物及其在精神分裂症诊断和预后检测的应用，该标志物为has‑miR‑132。我们研究表明miR‑132在精神分裂症患者外周血单个核细胞中的表达量低于正常人，miR‑132可以作为具有精神分裂症诊断和预后检测的一种生物标志物。本发明还提供了一种外周血miR‑132的检测方法，通过测定患者外周血miR‑132含量可以快速、准确的对精神分裂症作出诊断和预后疗效的鉴定，具有准确性高、方法简捷、成本低等优点。
摘要（英）：

The invention relates to a peripheral blood microRNA molecular marker and an application thereof in diagnosis and prognosis detection of schizophrenia, wherein the marker is has-miR-132. Researches show that the expression quantity of the miR-132 in a peripheral blood mononuclear cell is lower than that of a normal person, and so the miR-132 can be used as a biological marker for diagnosis and prognosis detection of the schizophrenia. The invention also provides a detection method of the peripheral blood miR-132. By measuring the content of the peripheral blood miR-132 of a patient, diagnosis and identification on a prognosis effect of the schizophrenia can be rapidly and accurately realized. The peripheral blood microRNA molecular marker has the advantages of high accuracy, simpleness in method, low cost and the like.

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