An operation management method for an electric power system cloud simulation platform. The electric power system cloud simulation platform comprises a cloud simulation resource management system and a cloud simulation application support system. The operation management method comprises the following steps: constructing a cloud simulation resource management system; constructing a cloud simulation application support system; determining the security of the electric power system cloud simulation platform; and performing operation management on the electric power system cloud simulation platform. The solution realizes the cloud simulation analysis and computation application, and supports multiple users to carry out the simulation computing functions such as power flow, transient stability, small interference, short-circuit current and the like on one set or multiple sets of data in a network service-oriented mode according to permissions, thereby solving the limitation of standalone-version software on sharing services and data in the large-scale interconnected power grid analysis and computation.