The invention relates to a portable tire pressure sensor wireless diagnostic device. The portable tire pressure sensor wireless diagnostic device comprises a single chip microcomputer; a first signal input end of the single chip microcomputer is connected with the output end of a high frequency receiving module which is used for receiving radio-frequency signal sent by a tire pressure sensor module; a first signal output end of the single chip microcomputer is connected with the input end of a low frequency transmitting module which is used for sending radio low-frequency signal to the tire pressure sensor module; a radio frequency receiving and transmitting module is arranged in the tire pressure sensor module; a second signal input end of the single chip microcomputer is connected with keys; a second signal output end of the single chip microcomputer is connected with a display; and both-way communication of the single chip microcomputer with a RS232 serial communications module is realized. According to the portable tire pressure sensor wireless diagnostic device, diagnosis and test on the tire pressure sensor module can be realized via radio frequency transmitting and receiving; removing of the tire pressure sensor module from tyres is not necessary; and diagnosis and testing are convenient. Debugging, testing, installing, and diagnosing of the tire pressure sensor module can be realized by the portable tire pressure sensor wireless diagnostic device; battery power supply is adopted by the portable tire pressure sensor wireless diagnostic device; and portability of the portable tire pressure sensor wireless diagnostic device is excellent.