The invention discloses a leather adhesive with high scratch resistance. The leather adhesive is prepared from raw materials namely dicyclohexylmethane diisocyanate, polypropylene oxide (polypropylene glycol) glycol, neopentyl glycol, waste rubber nano micro powder, 2,2-dimethylolpropionic acid, deionized water and carboxyl butadiene-styrene rubber. The adhesive is high in solid content, high in emulsion adhesion capacity, high in adhesion strength and excellent in film-forming property. An adhesive film formed by the adhesive has the characteristics of scraping resistance, high toughness and the like.