The invention provides a manual-control cigarette end pick-up device. A switch of a transmission mechanism of the device is connected with one end of a transmission iron wire, and the other end of the transmission iron wire is connected with a pick-up mechanism; a cigarette end sweeper of the pick-up mechanism is fixedly arranged on a cigarette end sweeper clamping plate; a first threaded rod is connected with the cigarette end sweeper clamping plate and a connecting bracket; the connecting bracket is connected with a box body; a second threaded rod of a walking mechanism is welded on the box body; a roller wheel is fixedly arranged on the second threaded rod; a handle is welded on the connecting rod; the connecting rod and a fixing rack are welded on a cigarette end recycling box. The device is manually controlled; the transmission mechanism is controlled to move by controlling the handle, so that the pick-up mechanism is driven to pickup cigarette ends. By virtue of the device, the multifarious labor work of workers is alleviated, and the workload is reduced; furthermore the manual-control cigarette end pick-up device is compact in design and structure, simple to operate and convenient to use.