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发明公开
CN104487092A 对于由阻碍整合素α8β1功能引起的纤维化的抑制 有权

对于由阻碍整合素α8β1功能引起的纤维化的抑制
摘要：
获得新型且有效的抗纤维化剂。使用含有整合素α8β1的拮抗剂的抗纤维化剂。或者，使用一种抗纤维化剂，其含有：与整合素α8链的帽端亚结构域中的至少1个氨基酸及其周边区域，特异结合的抗整合素α8β1抗体。或者，使用一种抗纤维化剂，其含有：与整合素α8链的R120及其周边区域，或S132及在其周边区域特异结合的抗整合素α8β1抗体。所述拮抗剂也可以是：例如，与来自人，小鼠，和大鼠的任意一个物种中的整合素α8β1，可以结合的抗整合素α8β1抗体。
摘要（英）：

The purpose of the present invention is to acquire a novel and efficacious anti-fibrosis agent. Use is made of an anti-fibrosis agent that comprises an integrin alpha8beta1 antagonist. Alternatively, use is made of an anti-fibrosis agent that comprises an anti-integrin alpha8beta1 antibody capable of specifically binding to at least one amino acid in a cap sub-domain of integrin alpha8 chain and the vicinity thereof. Alternatively, use is made of an anti-fibrosis agent that comprises an anti-integrin alpha8beta1 antibody capable of specifically binding to R120 of integrin alpha8 chain and the vicinity thereof, or S132 and the vicinity thereof. The aforesaid antagonist may be an anti-integrin alpha8beta1 antibody capable of binding to integrin alpha8beta1 of any origin, for example, human, mouse or rat.

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