The invention discloses a shock-resistant packaging box. The shock-resistant packaging box comprises a box bottom, retaining plates, a cover plate and an inflatable bag. The inflatable bag is arranged in an internal space formed by the box bottom and the retaining plates and covers the inner side of the box bottom, inflation pumps are arranged at corners formed by the box bottom and the retaining plates and are connected with the inflatable bag, and pressure sensors are arranged on the surfaces of the inflation pumps. The shock-resistant packaging box has the advantages that the shock-resistant packaging box is simple in structure, capable of inflating itself to have a buffer function in case of accidental falling due to the inflatable bag structure, high in shock resistance and capable of preventing damage to objects therein.