The invention discloses an ether liquid crystal compound and a preparation method and applications thereof. The compound is shown as the formula I in the specification. The molecular structure of the compound shown in the formula I contains a liquid crystal compound with R3 and R4-substitued methoxy linking group (-C(R3R4)O-), so that the ether liquid crystal compound not only has large dielectric anisotropy, more importantly, has high response speed and high clearing point, and the performance has extremely important significance with regards to the blending of the liquid crystal mixture.