The invention discloses a pneumatic compression and curing method for a self-lubricating bushing. The self-lubricating bushing comprises a bushing substrate and a PTFE fabric self-lubricating liner. A high temperature-resisting air bag which is cylindrical after air inflation is sleeved with the PTFE fabric self-lubricating liner, pneumatic compression is carried out on the air bag under room temperature via an inflator with a pressure meter; pressure in the air bag applies a force to the PTFE fabric self-lubricating liner until the pressure value on the pressure meter is the corrected value F1 of cured pressure and then air inflation is stopped and the air bag is sealed; the self-lubricating bushing with the air bag is put in an oven whose temperature is the room temperature T1; the oven is started to enable temperature inside the oven to reach the temperature T2 needed by curing of the PTFE fabric self-lubricating liner, the temperature T2 is kept for a period of time, and pressure suffered by the PTFE fabric self-lubricating liner is the cured pressure F2. The curing method has the advantages of greatly ensuring accuracy of cured pressure and reducing curing cost.