The invention relates to pharmaceutical equipment, in particular to a bottle pressing wheel synchronous drive device used on an ampoule bottle inker. The bottle pressing wheel synchronous drive device used on the ampoule bottle inker comprises a left wallboard, a right wallboard, a drive shaft, a driven shaft and a conveyer belt arranged on the drive shaft and the driven shaft in a sleeving mode, wherein the drive shaft and the driven shaft are arranged between the left wallboard and the right wallboard. The bottle pressing wheel synchronous drive device used on the ampoule bottle inker further comprises a supporting device, a bottle pressing device arranged over the conveyer belt through the supporting device, and a transmission device connected with the bottle pressing device; the supporting device comprises a shield arranged on the left wallboard and a fixing support arranged on the right wallboard and opposite to the shield; the bottle pressing device comprises a bottle pressing wheel shaft and a bottle pressing wheel arranged on the bottle pressing wheel shaft; the two ends of the bottle pressing wheel shaft are arranged on the shield and the fixing support respectively; the bottle pressing wheel shaft can vertically move on the shield and the fixing support. The bottle pressing wheel synchronous drive device used on the ampoule bottle inker is simple in structure, convenient to adjust, and high in degree of automation.