The invention relates to a hyaluronic acid-vitamin E succinate polymer as well as preparation and application thereof. Particularly, the hyaluronic acid-vitamin E succinate polymer is obtained by connecting vitamin E succinate with main-chain hyaluronic acid through a double-amido bridge chain, and the hyaluronic acid-vitamin E succinate polymer has a structural formula I as shown in the specification. Vitamin E succinate has high safety, low critical micelle concentration and good biocompatibility. The hyaluronic acid-vitamin E succinate polymer is simple in preparation process and is suitable for large-scale production. In addition, the carrying materials can be self-assembled into a micelle in an aqueous medium, can be used as carriers of oral or intravenous indissolvable medicines, genomic medicines, protein medicines and have great market application prospect.