The invention relates to a panel internal interface capable of being flexibly configured based on the system complexity and a protocol thereof. By means of a display panel driving system interface configuration method and a data transmission method, an end-to-end connection mode and a one-to-two connection mode can be formed through flexible configuration according to system requirements on the basis of not changing the design of a timing controller and a source driving chip, so that specific requirements of different panel systems are met. On the condition that the end-to-end mode meets the bandwidth requirement and the problem that system connection is too complex when many connecting lines are arranged is solved, the end-to-end connection is adopted. When the number of source driving chips in the system is too large, the problems that the number of connecting lines is too large and power consumption is higher will be caused if the end-to-end mode is adopted, the one-to-two mode can be adopted at the moment, the number of the connecting lines can be reduced by one half, and the complexity degree of the panel system is greatly lowered.