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发明公开
CN104546722A 米铂脂质体和制法 有权

米铂脂质体和制法
摘要：
本发明涉及米铂脂质体和制法。具体地说，本发明涉及一种呈液体形式的药物组合物，其中包含：米铂、磷脂、胆固醇和水。该药物组合物每1ml中米铂的量为0.1～50mg，所述米铂是以其无水物或者一水合物的形式添加的，所述磷脂选自：蛋黄卵磷脂、氢化蛋黄卵磷脂、大豆卵磷脂、氢化大豆卵磷脂、鞘磷脂、磷脂酰乙醇胺、二肉豆蔻酰磷脂酰胆碱(即DMPC)、二肉豆蔻酰磷脂酰甘油(即DMPG)、二棕榈酰磷脂酰胆碱、二硬酯酰磷脂酰胆碱、二油酰磷脂酰胆碱、二月桂酰磷脂酰胆碱、及其组合，米铂与磷脂的重量比为1:0.2～20，胆固醇与磷脂的重量比为0.1～1:1。本发明还提供了所述药物组合物的制备方法。本发明呈液体形式的脂质体药物组合物具有如说明书所述的优点。
摘要（英）：

The invention relates to miriplatin lipidosome and a preparation method thereof and in particular relates to a pharmaceutical composition in a liquid form. The pharmaceutical composition comprises miriplatin, phospholipid, cholesterol and water. According to the invention, the amount of miriplatin in every 1ml of pharmaceutical composition is 0.1-50mg; the miriplatin is added in an anhydride or monohydrate form; the phospholipid is selected from egg yolk lecithin, hydrogenated egg yolk lecithin, soya bean lecithin, hydrogenated soya bean lecithin, sphingomyelin, phosphatidyl ethanolamine, DMPC, dimyristoyl phosphatidylglycerol (DMPG), dipalmitoyl phosphatidyl choline, distearoyl phosphatidylcholine, dioleoylphosphocholine, DLPC and combinations thereof; the weight ratio of miriplatin to phospholipid is 1:(0.2-20); and the weight ratio of cholesterol to phospholipid is (0.1-1):1. The invention also provides a method for preparing the pharmaceutical composition. The lipidosome pharmaceutical composition in the liquid form has the advantages as shown in the specification.

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