The invention discloses a cluster measurement and control device for an intelligent transformer substation and a system with the cluster measurement and control device, and belongs to the technical field of power equipment measurement and control. The cluster measurement and control device for the intelligent transformer substation comprises 10-15 virtual measurement and control devices and a cluster task manager, wherein the cluster task manager is used for managing all the virtual measurement and control devices in the physical device and comprises a virtual measurement and control device state monitoring module, a task manager master-and-slave-token judging module, a virtual measurement and control device data synchronization function module and a virtual measurement and control device backup scheduling function module. According to the cluster measurement and control device for the intelligent transformer substation and the system with the cluster measurement and control device, the 10-15 virtual measurement and control devices are integrated into one cluster measurement and control device and are uniformly managed by the cluster task manager, so that the number of the measurement and control devices is greatly lowered; the cluster measurement and control device is provided with a backup, so that the reliability of the whole cluster system is guaranteed.